Ethan Lu, MD

Specialist
M_Neurology
+1 510 502-7285

I am an associate specialist of Neonatal Brain Disorder Laboratories. My research focuses on brain cholesterol synthesis and metabolism following neonatal brain hypoxia-ischemia. We use both in vivo mouse model (Vannucci procedure), and in vitro paradigm (oxygen-glucose deprivation in primary neurons) to study how hypoxia-ischemia regulates brain cholesterol homeostasis at early developmental stage; the unique pathway of cholesterol turnover in the brain; and the contribution of cholesterol dysfunction in brain structural and functional changes after neonatal hypoxia-ischemia.

In the routine lab work, I also assist with the management of mouse transgenic colonies and perform a variety of histological and molecular biology experiments.

Publications: 

Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Lu F, Fan S, Romo AR, Xu D, Ferriero DM, Jiang X

Fluoride related changes in behavioral outcomes may relate to increased serotonin.

Physiology & behavior

Lu F, Zhang Y, Trivedi A, Jiang X, Chandra D, Zheng J, Nakano Y, Abduweli Uyghurturk D, Jalai R, Onur SG, Mentes A, DenBesten PK

Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling.

Scientific reports

Minnella AM, Zhao JX, Jiang X, Jakobsen E, Lu F, Wu L, El-Benna J, Gray JA, Swanson RA

Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain.

Pediatric research

Lu F, Zhu J, Guo S, Wong BJ, Chehab FF, Ferriero DM, Jiang X

Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain.

Experimental neurology

Lu F, Shao G, Wang Y, Guan S, Burlingame AL, Liu X, Liang X, Knox R, Ferriero DM, Jiang X

NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia.

Stroke

Knox R, Brennan-Minnella AM, Lu F, Yang D, Nakazawa T, Yamamoto T, Swanson RA, Ferriero DM, Jiang X