I am an associate specialist of Neonatal Brain Disorder Laboratories. My research focuses on brain cholesterol synthesis and metabolism following neonatal brain hypoxia-ischemia. We use both in vivo mouse model (Vannucci procedure), and in vitro paradigm (oxygen-glucose deprivation in primary neurons) to study how hypoxia-ischemia regulates brain cholesterol homeostasis at early developmental stage; the unique pathway of cholesterol turnover in the brain; and the contribution of cholesterol dysfunction in brain structural and functional changes after neonatal hypoxia-ischemia.

In the routine lab work, I also assist with the management of mouse transgenic colonies and perform a variety of histological and molecular biology experiments.