Hypoxic-ischemic encephalopathy remains a significant cause of death and disability in infants and children. Our research efforts are centered on understanding the molecular mechanisms of oxidative injury and the excitotoxic signaling mediated by the NMDA-type glutamate receptors in the developing brain. In particular, we investigate the role of postsynaptic density proteins, including the family of membrane-associated guanylate kinases (MAGUKs) and the Src family kinases, in regulating NMDA receptor function and related signaling networks in neonatal brain ischemia. The long-term goal of the studies is to develop novel and specific therapeutic targets for neonatal brain hypoxia-ischemia and neonatal stroke.