Xiangning Jiang, PhD

Associate Adjunct Professor
Neurology
+1 415 502-1099

Hypoxic-ischemic encephalopathy remains a significant cause of death and disability in infants and children. Our research efforts are centered on understanding the molecular mechanisms of oxidative injury and the excitotoxic signaling mediated by the NMDA-type glutamate receptors in the developing brain. In particular, we investigate the role of postsynaptic density proteins, including the family of membrane-associated guanylate kinases (MAGUKs) and the Src family kinases, in regulating NMDA receptor function and related signaling networks in neonatal brain ischemia. The long-term goal of the studies is to develop novel and specific therapeutic targets for neonatal brain hypoxia-ischemia and neonatal stroke.

Publications: 

Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Lu F, Fan S, Romo AR, Xu D, Ferriero DM, Jiang X

Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling.

Scientific reports

Minnella AM, Zhao JX, Jiang X, Jakobsen E, Lu F, Wu L, El-Benna J, Gray JA, Swanson RA

Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain.

Pediatric research

Lu F, Zhu J, Guo S, Wong BJ, Chehab FF, Ferriero DM, Jiang X

Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain.

Experimental neurology

Lu F, Shao G, Wang Y, Guan S, Burlingame AL, Liu X, Liang X, Knox R, Ferriero DM, Jiang X

Cellular and molecular introduction to brain development.

Neurobiology of disease

Jiang X, Nardelli J

NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia.

Stroke

Knox R, Brennan-Minnella AM, Lu F, Yang D, Nakazawa T, Yamamoto T, Swanson RA, Ferriero DM, Jiang X

Phenotype and secretory responses to oxidative stress in microglia.

Developmental neuroscience

Pathipati P, Müller S, Jiang X, Ferriero D

Developmental localization of NMDA receptors, Src and MAP kinases in mouse brain.

Neuroscience letters

Jiang X, Knox R, Pathipati P, Ferriero D

Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayers.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Davis B, Tang J, Zhang L, Mu D, Jiang X, Biran V, Vexler Z, Ferriero DM

HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia.

Developmental neuroscience

Sheldon RA, Osredkar D, Lee CL, Jiang X, Mu D, Ferriero DM

Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia.

Annals of neurology

Jiang X, Mu D, Biran V, Faustino J, Chang S, Rincón CM, Sheldon RA, Ferriero DM

A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection.

Neuroscience letters

Hamrick SE, McQuillen PS, Jiang X, Mu D, Madan A, Ferriero DM

Differential vulnerability of immature murine neurons to oxygen-glucose deprivation.

Experimental neurology

Jiang X, Mu D, Manabat C, Koshy AA, Christen S, Täuber MG, Vexler ZS, Ferriero DM

Manipulation of antioxidant pathways in neonatal murine brain.

Pediatric research

Sheldon RA, Jiang X, Francisco C, Christen S, Vexler ZS, Täuber MG, Ferriero DM

Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model.

Neurobiology of disease

Mu D, Jiang X, Sheldon RA, Fox CK, Hamrick SE, Vexler ZS, Ferriero DM